The WomanStats Project is a donor-funded research and database project housed at Brigham Young University that "seeks to collect detailed statistical data on the status of women around the world, and to connect that data with data on the security of states." The WomanStats Database aims to provide a comprehensive compilation of information on the status of women in the world. Coders comb the extant literature and conduct expert interviews to find qualitative and quantitative information on over 300 indicators of women's status in 174 countries with populations of at least 200,000. Access to the online database is free. == History and structure == WomanStats began as an outgrowth of a paper Dr. Valerie M. Hudson (of the Brigham Young University Political Science department) and one of her graduate students, Andrea den Boer, published in International Security on the association between national security and the abnormal sex ratio in Asia. After the success and influence of their first article, (later added as one of their top twenty national security articles of that journal of all time), Hudson and den Boer did further research on the connection between the status of women and national security, but found that there was no single database that covered the range of topics that they needed for their research. Consequently, they began compiling information on variables regarding the status of women around the world. The database was officially formed in 2001 and grew exponentially as it later added more variables. The Project went live on the Internet in July 2007. The principal investigators are: Valerie M. Hudson (International Relations), Bonnie Ballif-Spanvill (Psychology, emeritus), and Chad F. Emmett (Geography) all from Brigham Young University, Mary Caprioli from the University of Minnesota, Duluth (International Relations), Rose McDermott from Brown University (International Relations), Andrea Den Boer from the University of Kent at Canterbury in the United Kingdom (International Relations) and S. Matthew Stearmer from the Ohio State University (Sociology; doctoral student). Approximately a dozen undergraduate and graduate students at Brigham Young University and Texas A&M University work at any one time as coders for the project. The coders take the raw quantitative and qualitative data collected in government reports, news articles, research papers, etc. and sort the applicable information on women into categories. They may also implement scales developed by the principal investigators, or that they (the students) themselves have developed. == Database == As of February 2011, the database has 307 variables, covers 174 nations with populations over 200,000, uses 18,015 sources and contains over 111,000 individual data points. All data is referenced to original sources. Not every variable has information for each country; similarly, not all countries have information for each variable: overall, about 70% of country-variable combinations have information. These database coding gaps exist where information is not available or is incomplete, or variables are not collected and reported by governments or international organizations. At times, information from different sources may be contradictory, and the WomanStats Database records this discrepant information for triangulation purposes. == Users and role of the database == The database is meant to help fill a hole in the extant data on the situation of women around the world. WomanStats data and research has been vetted and/or used by the United Nations, the United States Department of Defense, the Central Intelligence Agency, and the World Bank. Their data and research were also used by the United States Senate Committee on Foreign Relations in crafting the International Violence Against Women’s Act. The Inter-Agency Network on Women and Gender Equality (IANWGE) of the United Nations has stated that the WomanStats project "filled a major gap in the availability of data on women" (2007). Victor Asal and Mitchell Brown, researchers not affiliated with WomanStats, stated in an article published in Politics and Policy that "one of the most significant challenges of cross-national empirical studies of the prevalence of interpersonal violence is the paucity of available data, particularly reliable data," and that "WomanStats has allowed for an important first glimpse at analyzing the factors related to interpersonal violence." They conclude by stating that "Our findings suggest that, in the same way that larger disciplinary resources have invested in interstate and intrastate war, disciplinary resources need to be expended in creating a data set exploring interpersonal violence. Until the rights and the lives of women and children are taken as seriously as the survival of states by more proactively collaborating on projects like WomanStats, we will continue to only have a small lens through which to understand problems like this." Princeton University professor Evan S. Liberman wrote, "Although data on political regimes and group conflict have been in far greater demand by political scientists than data on gender politics and policies, two gender-related databases provide...examples of innovative HIRDs. Both the Womanstats database project (Hudson et al. 2009) and the Research Network on Gender Politics and the State (RNGS) project (McBride et al. 2008) are well-integrated presentations of quantitative and qualitative data characterizing the quality of gender relations around the world and, in particular, analytic descriptions of the treatment of women."." == Research == The research component of WomanStats focuses on exploring the relationship between the situation of women and the behavior and security of states. Current research initiatives include: Exploring the relationship between violent instability and inequity and family law. Examining the effect of polygyny and marriage market dislocations on the rise of suicide terrorism. Documenting discrepancies between laws on the books and cultural practices on the ground concerning gender issues. Investigating how well the situation of women predicts the peacefulness of nations-states, compared to their variables such as democracy, wealth, and civilization. The Project has published articles in International Security, International Studies Quarterly, Peace and Conflict, Journal of Peace Research, Political Psychology, Cumberland Law Review, and World Political Review, and has a forthcoming book from Columbia University Press.
Rapid PHP Editor
rapid PHP Editor is a PHP Editor that incorporates many functions such as AutoComplete, Syntax checker, debugger and many other tools for fast PHP development. Rapid PHP Editor also contain other development tools for helping on HTML, CSS, JavaScript and many other languages. Is part of a family of products covering most aspects of modern web development integrating as well many other capabilities used by developers. Some features: (X)HTML to HTML5 CSS to CSS3 Code intelligence Powerful search and replace Support for several frameworks Code beautifier FTP Explorer (FTP/SFTP/FTPS) File explorer Database explorer Code snippets Validators and Debuggers FAST, real fast Many other tools available (many more to describe all here) == History == Rapid PHP Editor was built using the Delphi programming language.
Jump-and-Walk algorithm
Jump-and-Walk is an algorithm for point location in triangulations (though most of the theoretical analysis were performed in 2D and 3D random Delaunay triangulations). Surprisingly, the algorithm does not need any preprocessing or complex data structures except some simple representation of the triangulation itself. The predecessor of Jump-and-Walk was due to Lawson (1977) and Green and Sibson (1978), which picks a random starting point S and then walks from S toward the query point Q one triangle at a time. But no theoretical analysis was known for these predecessors until after mid-1990s. Jump-and-Walk picks a small group of sample points and starts the walk from the sample point which is the closest to Q until the simplex containing Q is found. The algorithm was a folklore in practice for some time, and the formal presentation of the algorithm and the analysis of its performance on 2D random Delaunay triangulation was done by Devroye, Mucke and Zhu in mid-1990s (the paper appeared in Algorithmica, 1998). The analysis on 3D random Delaunay triangulation was done by Mucke, Saias and Zhu (ACM Symposium of Computational Geometry, 1996). In both cases, a boundary condition was assumed, namely, Q must be slightly away from the boundary of the convex domain where the vertices of the random Delaunay triangulation are drawn. In 2004, Devroye, Lemaire and Moreau showed that in 2D the boundary condition can be withdrawn (the paper appeared in Computational Geometry: Theory and Applications, 2004). Jump-and-Walk has been used in many famous software packages, e.g., QHULL, Triangle and CGAL.
Shapiro–Senapathy algorithm
The Shapiro—Senapathy algorithm (S&S) is a computational method for identifying splice sites in eukaryotic genes. The algorithm employs a Position Weight Matrix (PWM) scoring formula to predict donor and acceptor splice sites in any given gene. This methodology has been used to discover splice sites and disease-causing splice site mutations in the human genome, and has become a standard tool in clinical genomics. The S&S algorithm has been cited in thousands of clinical studies, according to Google Scholar. It has also formed the basis of widely used software, including Human Splicing Finder, SROOGLE, and Alamut, which identify splice sites and splice site mutations that cause disease. The algorithm has uncovered splicing mutations in diseases ranging from cancers to inherited disorders, and predicted the deleterious effects of these mutations including exon skipping, intron retention, and cryptic splice site activation. == The algorithm == A splice site defines the boundary between a coding exon and a non-coding intron in eukaryotic genes. The S&S algorithm employs a sliding window, corresponding to the length of the splice site motif, to scan a gene sequence and detect potential splice sites. For each sliding window, the algorithm calculates a score by comparing the nucleotide sequence to a Position Weight Matrix (PWM) derived from known splice sites. This formula generates a percentile score, indicating the likelihood that a given sequence functions as a donor or acceptor splice site. The majority of disease-causing mutations in the human genome are located in splice sites. Clinical genomics studies analyze the splice site scores generated by the S&S algorithm to predict the consequences of splice site mutations including exon skipping and intron retention. The algorithm's sensitivity to single-nucleotide changes allows it to determine mutations that may impact RNA splicing and contribute to disease. In addition to identifying real splice sites, the S&S algorithm has been used to discover cryptic splice sites — alternative splice sites activated by mutations — which may disrupt normal splicing. The algorithm detects mutations that lead to the activation of cryptic splice sites, which may be located proximal to real splice sites or deep within non-coding introns. It has thus been used to determine the causes of numerous diseases that are due to cryptic splicing. == Cancer gene discovery using S&S == The S&S algorithm has been used to identify splice-site mutations in genes associated with several cancers. For example, genes causing commonly occurring cancers including breast cancer, ovarian cancer, colorectal cancer, leukemia, head and neck cancers, prostate cancer, retinoblastoma, squamous cell carcinoma, gastrointestinal cancer, melanoma, liver cancer, Lynch syndrome, skin cancer, and neurofibromatosis have been found. In addition, splicing mutations in genes causing less commonly known cancers including gastric cancer, gangliogliomas, Li-Fraumeni syndrome, Loeys–Dietz syndrome, Osteochondromas (bone tumor), Nevoid basal cell carcinoma syndrome, and Pheochromocytomas have been identified. Specific mutations in different splice sites in various genes causing breast cancer (e.g., BRCA1, PALB2), ovarian cancer (e.g., SLC9A3R1, COL7A1, HSD17B7), colon cancer (e.g., APC, MLH1, DPYD), colorectal cancer (e.g., COL3A1, APC, HLA-A), skin cancer (e.g., COL17A1, XPA, POLH), and Fanconi anemia (e.g., FANC, FANA) have been uncovered. The mutations in the donor and acceptor splice sites in different genes causing a variety of cancers that have been identified by S&S are shown in Table 1. == Discovery of genes causing inherited disorders using S&S == Specific mutations in different splice sites in various genes that cause inherited disorders, including, for example, Type 1 diabetes (e.g., PTPN22, TCF1 (HCF-1A)), hypertension (e.g., LDL, LDLR, LPL), Marfan syndrome (e.g., FBN1, TGFBR2, FBN2), cardiac diseases (e.g., COL1A2, MYBPC3, ACTC1), eye disorders (e.g., EVC, VSX1) have been uncovered. A few example mutations in the donor and acceptor splice sites in different genes causing a variety of inherited disorders identified using S&S are shown in Table 2. == Genes causing immune system disorders == More than 100 immune system disorders affect humans, including inflammatory bowel diseases, multiple sclerosis, systemic lupus erythematosus, bloom syndrome, familial cold autoinflammatory syndrome, and dyskeratosis congenita. The Shapiro–Senapathy algorithm has been used to discover genes and mutations involved in many immune disorder diseases, including Ataxia telangiectasia, B-cell defects, epidermolysis bullosa, and X-linked agammaglobulinemia. Xeroderma pigmentosum, an autosomal recessive disorder is caused by faulty proteins formed due to new preferred splice donor site identified using S&S algorithm and resulted in defective nucleotide excision repair. Type I Bartter syndrome (BS) is caused by mutations in the gene SLC12A1. S&S algorithm helped in disclosing the presence of two novel heterozygous mutations c.724 + 4A > G in intron 5 and c.2095delG in intron 16 leading to complete exon 5 skipping. Mutations in the MYH gene, which is responsible for removing the oxidatively damaged DNA lesion are cancer-susceptible in the individuals. The IVS1+5C plays a causative role in the activation of a cryptic splice donor site and the alternative splicing in intron 1, S&S algorithm shows, guanine (G) at the position of IVS+5 is well conserved (at the frequency of 84%) among primates. This also supported the fact that the G/C SNP in the conserved splice junction of the MYH gene causes the alternative splicing of intron 1 of the β type transcript. Splice site scores were calculated according to S&S to find EBV infection in X-linked lymphoproliferative disease. Identification of Familial tumoral calcinosis (FTC) is an autosomal recessive disorder characterized by ectopic calcifications and elevated serum phosphate levels and it is because of aberrant splicing. == Application of S&S in hospitals for clinical practice and research == The Shapiro–Senapathy (S&S) algorithm has played a significant role in advancing the diagnosis and treatment of human diseases through its application in modern clinical genomics. With the widespread adoption of next-generation sequencing (NGS) technologies, the S&S algorithm is now routinely integrated into clinical practice by geneticists and diagnostic laboratories. It is implemented in various computational tools such as Human Splicing Finder (HSF), Splice Site Finder (SSF), and Alamut Visual, which assist in interpreting the functional impact of genetic variants on RNA splicing. The algorithm is particularly useful in identifying pathogenic splice site mutations in cases where the clinical presentation is unclear or where conventional diagnostic methods have failed to identify a causative gene. Its utility has been demonstrated across diverse patient cohorts, including individuals from different ethnic backgrounds with various cancers and inherited genetic disorders. The following are selected examples illustrating its application in clinical research. === Cancers === === Inherited disorders === == S&S - Algorithm for identifying splice sites, exons and split genes == The Shapiro–Senapathy algorithm (SSA) was developed to identify splice sites in uncharacterized genomic sequences, with early applications in the Human Genome Project. The method introduced a Position Weight Matrix (PWM)-based approach to analyze splicing sequences across eukaryotic organisms, marking the first computational framework to systematically define splice sites using probabilistic scoring. Key innovations of the algorithm included: Exon Detection – Exons were defined as sequences bounded by acceptor and donor splice sites with S&S scores above a threshold, requiring an open reading frame (ORF) for validation. Gene Prediction – The method enabled the identification of complete genes by assembling predicted exons, forming a basis for later gene-finding tools. Mutation Analysis – The algorithm distinguishes deleterious splice-site mutations (which disrupt protein function by lowering S&S scores) from neutral variations. This capability allowed researchers to study disease-linked cryptic splice sites in humans, animals, and plants. SSA's PWM-based framework influenced subsequent computational methods, including machine learning and neural network approaches, for splice-site prediction and alternative splicing research. It remains a foundational tool in genomics and disease studies. == Discovering the mechanisms of aberrant splicing in diseases == The Shapiro–Senapathy algorithm has been used to determine the various aberrant splicing mechanisms in genes due to deleterious mutations in the splice sites, which cause numerous diseases. Deleterious splice site mutations impair the normal splicing of the gene transcripts, and thereby make the encoded protei
Archetype (information science)
In the field of informatics, an archetype is a formal re-usable model of a domain concept. Traditionally, the term archetype is used in psychology to mean an idealized model of a person, personality or behaviour (see Archetype). The usage of the term in informatics is derived from this traditional meaning, but applied to domain modelling instead. An archetype is defined by the OpenEHR Foundation (for health informatics) as follows: An archetype is a computable expression of a domain content model in the form of structured constraint statements, based on some reference model. openEHR archetypes are based on the openEHR reference model. Archetypes are all expressed in the same formalism. In general, they are defined for wide re-use, however, they can be specialized to include local particularities. They can accommodate any number of natural languages and terminologies. == Formal specifications == The modern archetype formalism is specified and maintained by the openEHR Foundation, and although originally developed for the health IT domain, is completely domain-independent, and has been used in geospatial modelling, telecommunications, and defence. The archetype formalism consists of a number of specifications including: 'ADL 1.4': original release of Archetype Definition Language (ADL) and Archetype Object Model (AOM); widely implemented in health IT domain; 'ADL 2': modern release of Archetype Definition Language (ADL), Archetype Object Model (AOM), Archetype Identification specification and Archetype Technology Overview. The Archetype Technology Overview provides a short technical overview of the archetype formalism useful for new users. The ADL/AOM 1.4 specifications were provided to ISO TC 215 in 2008 by the openEHR Foundation and became the ISO 13606-2 standard, extant until 2019. ISO TC 215 accepted the AOM 2 specification as the basis for a revision of this standard, which was issued in 2019. In late 2015, the Object Management Group (OMG) accepted an RfP entitled 'Archetype Modeling Language (AML)' as a new candidate standard. This specification is a form of ADL re-engineered as a UML profile so as to enable archetype modelling to be supported within UML tools. == Tools == A number of tools area available for working with archetypes. Most are listed on the openEHR modelling tools page. They include: ADL Designer, a modern AOM2-based web editing application Archetype Editor, an original desktop clinical modelling tool Template Designer, an original desktop clinical templating tool LinkEHR, an archetype and data integration tool ADL Workbench, reference compiler and visualiser tool == Example ==
Traceability
Traceability is the capability to trace something. In some cases, it is interpreted as the ability to verify the history, location, or application of an item by means of documented recorded identification. Other common definitions include the capability (and implementation) of keeping track of a given set or type of information to a given degree, or the ability to chronologically interrelate uniquely identifiable entities in a way that is verifiable. Traceability is applicable to measurement, supply chain, software development, healthcare and security. == Measurement == The term measurement traceability or metrological traceability is used to refer to an unbroken chain of comparisons relating an instrument's measurements to a known standard. Calibration to a traceable standard can be used to determine an instrument's bias, precision, and accuracy. It may also be used to show a chain of custody—from current interpretation of evidence to the actual evidence in a legal context, or history of handling of any information. In many countries, national standards for weights and measures are maintained by a National Metrological Institute (NMI) which provides the highest level of standards for the calibration / measurement traceability infrastructure in that country. Examples of government agencies include the National Physical Laboratory, UK (NPL) the National Institute of Standards and Technology (NIST) in the USA, the Physikalisch-Technische Bundesanstalt (PTB) in Germany, the Instituto Nazionale di Ricerca Metrologica (INRiM) in Italy, and the National Research Council of Canada (NRC). As defined by NIST, "Traceability of measurement requires the establishment of an unbroken chain of comparisons to stated references each with a stated uncertainty." A clock providing traceable time is traceable to a time standard such as Coordinated Universal Time or International Atomic Time. The Global Positioning System is a source of traceable time. === Food processing === In food processing (meat processing, fresh produce processing), the term traceability refers to the recording through means of barcodes or RFID tags and other tracking media, all movement of product and steps within the production process. One of the key reasons this is such a critical point is in instances where an issue of contamination arises, and a recall is required. Where traceability has been closely adhered to, it is possible to identify, by precise date/time and exact location which goods must be recalled, and which are safe, potentially saving millions of dollars in the recall process. Traceability within the food processing industry is also utilised to identify key high production and quality areas of a business, versus those of low return, and where points in the production process may be improved. In food processing software, traceability systems imply the use of a unique piece of data (e.g., order date/time or a serialized sequence number, generally through the use of a barcode / RFID) which can be traced through the entire production flow, linking all sections of the business, including suppliers and future sales through the supply chain. Messages and files at any point in the system can then be audited for correctness and completeness, using the traceability software to find the particular transaction and/or product within the supply chain. In food systems, ISO 22005, as part of the ISO 22000 family of standards, has been developed to define the principles for food traceability and specifies the basic requirements for the design and implementation of a feed and food traceability system. It can be applied by an organization operating at any step in the feed and food chain. The European Union's General Food Law came into force in 2002, making traceability compulsory for food and feed operators and requiring those businesses to implement traceability systems. The EU introduced its Trade Control and Expert System, or TRACES, in April 2004. The system provides a central database to track movement of animals within the EU and from third countries. Australia has its National Livestock Identification System to keep track of livestock from birth to slaughterhouse. India has started taking initiatives for setting up traceability systems at Government and Corporate levels. Grapenet, an initiative by Agriculture and Processed Food Products Export Development Authority (APEDA), Ministry of Commerce, Government of India is an example in this direction. GrapeNet is an internet based traceability software system for monitoring fresh grapes exported from India to the European Union. GrapeNet is a first of its kind initiative in India that has put in place an end-to-end system for monitoring pesticide residue, achieve product standardization and facilitate tracing back from pallets to the farm of the Indian grower, through the various stages of sampling, testing, certification and packing. Grapenet won the National Award (Gold), in the winners announced for the best e-Governance initiatives undertaken in India in 2007. The Directorate Generate Foreign Trade (DGFT), Government of India, through its notification dated 04.02.2009 relating to Amendment in Foreign Trade Policy (RE2008)has mandated that Export to the European Union is permitted subject to registration with APEDA, thereby making Grapenet mandatory for all exports of fresh grapes from India to Europe. Uruguay has also designed a system called "Traceability & Electronic Information System of the Beef Industry". Traceability in food supply can also refer to practices employed by individual companies, including Ritual and Amway's Nutrilite. In the case of Nutrilite's supplements, ingredients are documented and tested throughout farming, processing, and manufacturing to ensure traceability at each stage of production. == Systems and software development == In systems and software development, the term traceability (or requirements traceability) refers to the ability to link product requirements back to stakeholders' rationales and forward to corresponding design artifacts, code, and test cases. Traceability supports numerous software engineering activities such as change impact analysis, compliance verification or traceback of code, regression test selection, and requirements validation. It is usually accomplished in the form of a matrix created for the verification and validation of the project. Unfortunately, the practice of constructing and maintaining a requirements trace matrix (RTM) can be very arduous and over time the traces tend to erode into an inaccurate state unless date/time stamped. Alternate automated approaches for generating traces using information retrieval methods have been developed. The IEEE defines traceability as "(1)The degree to which a relationship can be established between two or more products of the development process, especially products having a predecessor, successor or master-subordinate relationship to one another. For example, the degree to which the requirements and design of a given software component match. See also: consistency. " and "(2) The degree to which each element in a software development product establishes its reason for existing; for example, the degree to which each element in a bubble chart references the requirement that it satisfies." In transaction processing software, traceability implies use of a unique piece of data (e.g., order date/time or a serialized sequence number) which can be traced through the entire software flow of all relevant application programs. Messages and files at any point in the system can then be audited for correctness and completeness, using the traceability key to find the particular transaction. This is also sometimes referred to as the transaction footprint. == Health care == Patient safety during healthcare service plays an important role in preventing delayed recovery or even mortality, by increasing and improving the quality of life of citizens, and is considered an indicator of the quality status of health services Maintaining patient safety is a complex task and involves factors inherent to the environment and human actions. New technologies facilitate the traceability tools of patients and medications. This is particularly relevant for drugs that are considered high risk and cost. Recent research in the healthcare industry emphasizes the significant impact of Blockchain Technology (BCT) on improving the performance of healthcare supply chain management. It highlights BCT's role in enhancing transparency, data immutability, and efficient management, leading to better cooperation among stakeholders and effective risk mitigation in healthcare services. The World Health Organization has recognized the importance of traceability for medical products of human origin (MPHO) and urged member states "to encourage the implementation of globally consistent coding systems to facilitate national and international traceability". == Security and cri
OpenWSN
OpenWSN aims to build an open standard-based and open source implementation of a complete constrained network protocol stack for wireless sensor networks and Internet of Things. The project was created at the University of California Berkeley and extended at the INRIA and at the Open University of Catalonia (UOC). The root of OpenWSN is a deterministic MAC layer implementing the IEEE 802.15.4e TSCH based on the concept of Time Slotted Channel Hopping (TSCH). Above the MAC layer, the Low Power Lossy Network stack is based on IETF standards including the IETF 6TiSCH management and adaptation layer (a minimal configuration profile, 6top protocol and different scheduling functions). The stack is complemented by an implementation of 6LoWPAN, RPL in non-storing mode, UDP and CoAP, enabling access to devices running the stack from the native IPv6 through open standards. OpenWSN is related to other projects including the following: RIOT OpenMote OpenWSN is available for Linux, Windows and OS X platforms. Current release of OpenWSN is 1.14.0.